Search for unstable DNA in schizophrenia families with evidence for genetic anticipation.

Article

Search for unstable DNA in schizophrenia families with evidence for genetic anticipation.

American journal of human genetics - 1 Oct 1996

Petronis A, Bassett A S, Honer W G, Vincent J B, Tatuch Y, Sasaki T, Ying D J, Klempan T A, Kennedy J L

Abstract excerpt

Evidence for genetic anticipation has recently become an important subject of research in clinical psychiatric genetics. Renewed interest in anticipation was evoked by molecular genetic findings of a novel type of mutation termed "unstable DNA." The unstable DNA model can be construed as the "bes...

Topics

Blotting, Southern
DNA
Electrophoresis, Polyacrylamide Gel
Female
Humans
Male
Mutation
Pedigree
Polymerase Chain Reaction
Schizophrenia
Trinucleotide Repeats

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