Article
Hereditary unstable DNA: a new explanation for some old genetic questions?
Lancet (London, England) - 3 Aug 1991
Sutherland G R, Haan E A, Kremer E, Lynch M, Pritchard M, Yu S, Richards R I
Abstract excerpt
Fragile X syndrome, associated with the fragile X chromosome, is the most common cause of familial mental retardation. The condition is characterised by a heritable DNA sequence that consists of an abnormal number of CCG repeats, and which is unstable in both mitosis and meiosis. We suggest that...
Topics
- Chromosome Fragility
- DNA
- Female
- Fragile X Syndrome
- Gene Expression Regulation
- Genetic Diseases, Inborn
- Genetic Linkage
- Genotype
- Humans
- Male
- Mutation
- Myotonia Congenita
- Phenotype
- Sex Chromosome Aberrations
- X Chromosome