Article
Genetic anticipation in schizophrenia: pro and con.
Clinical neuroscience (New York, N.Y.) - 1 Jan 1995
Petronis A, Sherrington R P, Paterson A D, Kennedy J L
Abstract excerpt
Recently, it has been demonstrated that unstable trinucleotide repeats are the etiologic factor in myotonic dystrophy, fragile-X syndrome, Kennedy's disease, Huntington's disease, spinocerebellar ataxia type 1, and dentatorubral-pallidoluysian atrophy. All available evidence suggests that these expanded trinucleotide repeats, or unstable DNA, are the biological basis of the clinical phenomenon of genetic...
Topics
- Age of Onset
- Base Sequence
- DNA
- Humans
- Huntington Disease
- Molecular Sequence Data
- Mutation
- Repetitive Sequences, Nucleic Acid
- Schizophrenia
- Severity of Illness Index