Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The E6 variant proteins E6I-E6IV of human papillomavirus 16: expression in cell free systems and bacteria and study of their interaction with p53.

Virus research - 1 Jun 1996

Shally M, Alloul N, Jackman A, Muller M, Gissmann L, Sherman L

Abstract excerpt

Several species of alternatively spliced mRNAs are transcribed from the E6 gene region of human papillomavirus (HPV) 16. These have the coding capacity for either the full length E6 of 151 amino acids (aa) or four truncated variants, E6I-E6IV, of 43-64 aa. As the first step to identify the putati...

Topics

Amino Acid Sequence
Animals
Cell-Free System
Escherichia coli
Gene Expression
Genetic Variation
Humans
Molecular Sequence Data
Oncogene Proteins, Viral
Papillomaviridae
Protein Biosynthesis
Rabbits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Repressor Proteins

Transcription, Genetic

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 8806176
DOI: 10.1016/0168-1702(96)01301-9

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8806176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The E6 variant proteins E6I-E6IV of human papillomavirus 16: expression in cell free systems and bacteria and study of their interaction with p53.PMID 8806176Read ↗

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Semantic proximity Read ↗

Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy.Semantic proximity Read ↗

Association of human papillomavirus types 16 and 18 E6 proteins with p53.Semantic proximity Read ↗

Interaction of HPV E6 with p53 and associated proteins.Semantic proximity Read ↗

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Semantic proximity Read ↗

Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.Semantic proximity Read ↗

Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex FormationSemantic proximity Read ↗

Isolation and functional analysis of five HPVE6 variants with respect to p53 degradation.Semantic proximity Read ↗

Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro.Semantic proximity Read ↗

Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.Semantic proximity Read ↗

Activities of human papillomavirus 16 E6 natural variants in human keratinocytes.Semantic proximity Read ↗

Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.