Article
The role of HLA-DR alleles and complotypes through the ethnic barrier in systemic lupus erythematosus in Mexicans.
Lupus - 1 Jun 1996
Granados J, Vargas-Alarcón G, Andrade F, Melín-Aldana H, Alcocer-Varela J, Alarcón-Segovia D
Abstract excerpt
Alleles of the major histocompatibility complex (MHC) have been recognized as genetic factors for the development of SLE. The [HLA-B8; SC01; DR3] extended haplotype seems to be relevant in patients from white European descent, pertinent alleles, however, are difficult to select on haplotypes with linkage disequilibrium. Studies in non-Caucasian patients are therefore mandatory. Admixture estimates in Mexicans...
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