Article
Class II allele and haplotype frequencies in Mexican systemic lupus erythematosus patients: the relevance of considering homologous chromosomes in determining susceptibility.
Human immunology - 1 Aug 2001
Vargas-Alarcón G, Salgado N, Granados J, Gómez-Casado E, Martinez-Laso J, Alcocer-Varela J, Arnaiz-Villena A, Alarcón-Segovia D
Abstract excerpt
The aim of the present study was to determine the relevant major histocompatibility complex (MHC) class II alleles in the genetic susceptibility to systemic lupus erythematosus (SLE) in Mexican Mestizo patients. We examined the gene and haplotype frequencies of the HLA-DRB1, DQA1 and DQB1 alleles by polymerase chain reaction-sequence-specific oligonucleotide probes in 81 Mexican SLE Mestizo patients and 99...
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