Article
Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.
Journal of neurology - 1 Jun 1996
Bronzova J, van Duijn C M, Havekes L M, de Knijff P, Van Broeckhoven C, Hofman A
Abstract excerpt
We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there...
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