[Greater sensitivity of the PCR-SSCP technique compared with immunohistochemistry for the detection of exon 5 and 6 mutations of gene 53 in breast cancer].

Abstract excerpt

BACKGROUND: p53 mutations constitute the most frequent genetic abnormality observed in breast cancer. The molecular study of p53 mutations not only provides prognostic information but also allows a better understanding of tumor biology. Most of the studies on p53 have been done by immunohistochemistry procedures. In this study we compare the sensitivity of immunohistochemistry and molecular genetics methods for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to DNA Mutational Analysis