Article
Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996
Macen J L, Garner R S, Musy P Y, Brooks M A, Turner P C, Moyer R W, McFadden G, Bleackley R C
Abstract excerpt
Cytotoxic T lymphocytes are important effectors of antiviral immunity, and they induce target cell death either by secretion of cytoplasmic granules containing perforin and granzymes or by signaling through the Fas cell surface antigen. Although it is not known whether the granule-mediated and Fas-mediated cytolytic mechanisms share common components, proteinase activity has been implicated as an important...
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