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Article

A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cells

1 Dec 1995

Abstract excerpt

Poxviruses are unique among viruses in encoding members of the serine proteinase inhibitor (serpin) superfamily. Orthopoxviruses contain three serpins, designated SPI-1, SPI-2, and SPI-3. SPI-1 encodes a 40-kDa protein that is required for the replication of rabbitpox virus (RPV) in PK-15 or A549 cells in culture (A. N. Ali, P. C. Turner, M. A. Brooks, and R. W. Moyer, Virology 202:305-314, 1994). Examination of...

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Identifiers

PMID: 7494278
DOI: 10.1128/jvi.69.12.7688-7698.1995

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Research trail→

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A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cellsPMID 7494278Read ↗

Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication.Semantic proximity Read ↗

Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants.Semantic proximity Read ↗

Poxviruses Utilize Multiple Strategies to Inhibit ApoptosisSemantic proximity Read ↗

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1Semantic proximity Read ↗

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Poxviral Strategies to Overcome Host Cell ApoptosisSemantic proximity Read ↗

SPI-1 is a missing host-range factor required for replication of the attenuated modified vaccinia Ankara (MVA) vaccine vector in human cellsSemantic proximity Read ↗

Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.Semantic proximity Read ↗

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1Semantic proximity Read ↗

The SPI-1 gene of rabbitpox virus determines host range and is required for hemorrhagic pock formation.Semantic proximity Read ↗

An orthopoxvirus serpinlike gene controls the ability of infected cells to fuse.Semantic proximity Read ↗

Induction of Apoptosis by Paramyxovirus Simian Virus 5 Lacking a Small Hydrophobic GeneSemantic proximity Read ↗

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