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Article

An orthopoxvirus serpinlike gene controls the ability of infected cells to fuse.

Journal of virology - 1 Apr 1992

Turner P C, Moyer R W

Abstract excerpt

Most orthopoxviruses encode a functional hemagglutinin (HA), which is nonessential for virus growth in cell culture. However, inactivation of the HA gene leads to the formation of polykaryocytes (syncytia) by fusion of infected cells at neutral pH. Fusion is not observed when a functional HA gene is present. Deletion of open reading frames (ORFs) K2, K3, and K4 within the HindIII K fragment of the HA-positive...

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Identifiers

PMID: 1548753
DOI: 10.1128/JVI.66.4.2076-2085.1992
PMCID: PMC288998

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