Article
An orthopoxvirus serpinlike gene controls the ability of infected cells to fuse.
Journal of virology - 1 Apr 1992
Turner P C, Moyer R W
Abstract excerpt
Most orthopoxviruses encode a functional hemagglutinin (HA), which is nonessential for virus growth in cell culture. However, inactivation of the HA gene leads to the formation of polykaryocytes (syncytia) by fusion of infected cells at neutral pH. Fusion is not observed when a functional HA gene is present. Deletion of open reading frames (ORFs) K2, K3, and K4 within the HindIII K fragment of the HA-positive...
Topics
- Antibodies, Monoclonal
- Base Sequence
- Blotting, Southern
- Blotting, Western
- Cell Fusion
- Cell Line
- DNA, Viral
- Hemagglutinins, Viral
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Polymerase Chain Reaction