Article
Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus.
Journal of virology - 1 Oct 1998
Messud-Petit F, Gelfi J, Delverdier M, Amardeilh M F, Py R, Sutter G, Bertagnoli S
Abstract excerpt
Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus inhibiting the cleavage of pro-IL-1beta by the pr...
Topics
- Animals
- Antigens, Surface
- Antigens, Viral
- Base Sequence
- Caspase 1
- Cell Line
- Chick Embryo
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- DNA Primers
- HeLa Cells
- Humans
- Mutation
- Myxoma virus
- Myxomatosis, Infectious
- Rabbits
- Sequence Deletion
- Tumor Necrosis Factor-alpha