Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication.

Journal of virology - 1 Jul 2005

Luttge Benjamin G, Moyer Richard W

Abstract excerpt

The orthopoxvirus serpin SPI-1 is an intracellular serine protease inhibitor that is active against cathepsin G in vitro. Rabbitpox virus (RPV) mutants with deletions of the SPI-1 gene grow on monkey kidney cells (CV-1) but do not plaque on normally permissive human lung carcinoma cells (A549). This reduced-host-range (hr) phenotype suggests that SPI-1 may interact with cellular and/or other viral proteins. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to DNA Replication
Share to Genes, Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomic Library

Share to Open Reading Frames

Share to Serpins

Share to Vaccinia virus

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 15994811
DOI: 10.1128/JVI.79.14.9168-9179.2005
PMCID: PMC1168772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication.PMID 15994811Read ↗

Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants.Semantic proximity Read ↗

A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cellsSemantic proximity Read ↗

The SPI-1 gene of rabbitpox virus determines host range and is required for hemorrhagic pock formation.Semantic proximity Read ↗

SPI-1 is a missing host-range factor required for replication of the attenuated modified vaccinia Ankara (MVA) vaccine vector in human cellsSemantic proximity Read ↗

Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode M(r) 38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model.Semantic proximity Read ↗

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1Semantic proximity Read ↗

C7L Family of Poxvirus Host Range Genes Inhibits Antiviral Activities Induced by Type I Interferons and Interferon Regulatory Factor 1Semantic proximity Read ↗

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKRSemantic proximity Read ↗

The cowpox virus SPI-3 and myxoma virus SERP1 serpins are not functionally interchangeable despite their similar proteinase inhibition profiles in vitro.Semantic proximity Read ↗

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1Semantic proximity Read ↗

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKRSemantic proximity Read ↗

An orthopoxvirus serpinlike gene controls the ability of infected cells to fuse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.