Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Combinatorial Library Strategy for the Rapid Humanization of Anticarcinoma BR96 Fab

1 Sept 1996

Abstract excerpt

We have used a combinatorial mutagenesis strategy to humanize BR96, a monoclonal antibody that binds to the Lewis Y class of tumor antigens. This approach allows simultaneous assessment of hundreds of humanized variable regions to identify the molecules that best preserve affinity, thus overcoming the major drawback of current humanization procedures, the requirement to construct and analyze each humanized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Biosensing Techniques and Applications
Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8798431
DOI: 10.1074/jbc.271.37.22611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Combinatorial Library Strategy for the Rapid Humanization of Anticarcinoma BR96 FabPMID 8798431Read ↗

A universal combinatorial design of antibody framework to graft distinct CDR sequences: a bioinformatics approach.Semantic proximity Read ↗

Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab LibrarySemantic proximity Read ↗

A phage display approach for rapid antibody humanization: Designed combinatorial V gene librariesSemantic proximity Read ↗

HuCAL PLATINUM, a synthetic Fab library optimized for sequence diversity and superior performance in mammalian expression systems.Semantic proximity Read ↗

Humanization of murine monoclonal antibodies through variable domain resurfacing.Semantic proximity Read ↗

AXL-Receptor Targeted 14FN3 Based Single Domain Proteins (Pronectins™) from 3 Synthetic Human Libraries as Components for Exploring Novel Bispecific Constructs against Solid TumorsSemantic proximity Read ↗

Antibody Humanization Using Monovalent Phage DisplaySemantic proximity Read ↗

A Human Synthetic Combinatorial Library of Arrayable Single-chain Antibodies based on Shuffling in Vivo Formed CDRs into General Framework RegionsSemantic proximity Read ↗

Humanization of rabbit monoclonal antibodies via grafting combined Kabat/IMGT/Paratome complementarity-determining regions: Rationale and examplesSemantic proximity Read ↗

Structural diversity in a human antibody germline librarySemantic proximity Read ↗

The x-ray structure of an anti-tumour antibody in complex with antigen.Semantic proximity Read ↗

An efficient route to human bispecific IgG.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.