Article
The x-ray structure of an anti-tumour antibody in complex with antigen.
Nature structural biology - 1 Jun 1995
Jeffrey P D, Bajorath J, Chang C Y, Yelton D, Hellström I, Hellström K E, Sheriff S
Abstract excerpt
The crystal structures of the murine BR96 Fab and its human chimera have been determined in complex with the nonoate methyl ester derivative of Lewis Y (nLey) at 2.8 A and 2.5 A resolution, respectively. BR96 binds the carbohydrate in a large pocket which is formed by residues of all CDR loops except L2. The binding of the carbohydrate is mediated predominantly by aromatic residues in BR96. Analysis of the...
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