Article
The x-ray structure of an anti-tumour antibody in complex with antigen.
Nature structural biology - 1 Jun 1995
Jeffrey P D, Bajorath J, Chang C Y, Yelton D, Hellström I, Hellström K E, Sheriff S
Abstract excerpt
The crystal structures of the murine BR96 Fab and its human chimera have been determined in complex with the nonoate methyl ester derivative of Lewis Y (nLey) at 2.8 A and 2.5 A resolution, respectively. BR96 binds the carbohydrate in a large pocket which is formed by residues of all CDR loops ex...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Neoplasm
- Binding Sites, Antibody
- Carbohydrate Sequence
- Crystallography, X-Ray
- Humans
- Immunoglobulin Fab Fragments
- Lewis Blood Group Antigens
- Mice
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Neoplasms
- Protein Conformation
- Recombinant Fusion Proteins