Article
E-cadherin gene mutations in signet ring cell carcinoma of the stomach.
Japanese journal of cancer research : Gann - 1 Aug 1996
Muta H, Noguchi M, Kanai Y, Ochiai A, Nawata H, Hirohashi S
Abstract excerpt
To clarify the significance of E-cadherin gene alterations in the development of diffuse-type adenocarcinoma of the stomach, we analyzed mutations of the E-cadherin gene using the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) method followed by direct sequencing. Twenty-two signet ring cell carcinomas of the stomach (10 intramucosal and 12 advanced cancers) were examined. Genomic...
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