Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Presenilin affects arm/beta-catenin localization and function in Drosophila.

Developmental biology - 15 Nov 2000

Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik K S

Abstract excerpt

Presenilin is an essential gene for development that when disrupted leads to a neurogenic phenotype that closely resembles Notch loss of function in Drosophila. In humans, many naturally occurring mutations in Presenilin 1 or 2 cause early onset Alzheimer's disease. Both loss of expression and overexpression of Presenilin suggested a role for this protein in the localization of Armadillo/beta-catenin. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Armadillo Domain Proteins
Share to beta Catenin
Share to Catenins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules

Share to Delta Catenin

Share to Insect Proteins

Share to Presenilin-1

Share to Receptors, Notch

Source

Identifiers

PMID: 11071766
DOI: 10.1006/dbio.2000.9925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presenilin affects arm/beta-catenin localization and function in Drosophila.PMID 11071766Read ↗

Roles of Armadillo, a Drosophila catenin, during central nervous system development.Semantic proximity Read ↗

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.Semantic proximity Read ↗

A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.Semantic proximity Read ↗

A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin.Semantic proximity Read ↗

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.Semantic proximity Read ↗

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Semantic proximity Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.Semantic proximity Read ↗

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.Semantic proximity Read ↗

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.Semantic proximity Read ↗

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.Semantic proximity Read ↗

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome SegregationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.