Detection of genome similarity as an exploratory tool for mapping complex traits.

doi:10.1002/gepi.1370120658

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Article

Detection of genome similarity as an exploratory tool for mapping complex traits.

Genetic epidemiology - 1 Jan 1995

Guo S W

Abstract excerpt

For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical by descent (IBD) conditional on observed marker data. These results can...

Topics

Alleles
Chromosome Mapping
Genetic Markers
Genome, Human
Humans
Lod Score
Models, Genetic
Pedigree
Phenotype
Probability

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