New betaclamycin and aclarubicin analogs obtained by prolonged microbial conversion with an aclarubicin-negative mutant.

doi:10.7164/antibiotics.49.669

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Article

New betaclamycin and aclarubicin analogs obtained by prolonged microbial conversion with an aclarubicin-negative mutant.

The Journal of antibiotics - 1 Jul 1996

Johdo O, Yoshioka T, Naganawa H, Takeuchi T, Yoshimoto A

Abstract excerpt

Microbial conversion of beta-rhodomycinone and aklavinone using an aclarubicin-negative Streptomyces galilaeus mutant afforded new anthracycline antibiotics CG21-C and CG1-C which had a rednosyl-2-deoxyfucosyl-rhodosaminyl trisaccharide residue at C-7 of each added aglycone. They were produced on...

Topics

Aclarubicin
Animals
Anthracyclines
Antibiotics, Antineoplastic
Cell Division
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Mutation
Streptomyces
Tumor Cells, Cultured

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