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Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents

16 Oct 2020

Abstract excerpt

Abstract Anthracycline anticancer drugs doxorubicin and aclarubicin have been used in the clinic for several decades to treat various cancers. Although closely related structures, their molecular mode of action diverges, which is reflected in their biological activity profile. For a better understanding of the structure–function relationship of these drugs, we synthesized ten doxorubicin/aclarubicin hybrids...

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PMID: 33064004
DOI: 10.1021/acs.jmedchem.0c01191

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