Article
[Biosynthesis of anthracycline: a new interpretation of the results for daunomycin biosynthesis].
Journal of basic microbiology - 1 Jan 1991
Wagner C, Eckardt K, Ihn W, Schumann G, Stengel C, Fleck W F, Tresselt D
Abstract excerpt
On the basis of literature data and our own experiments the "late" biosynthetic pathway to daunomycin has been interpreted from a new point of view considering both the in vivo biosynthesis and formation of shunt products. In contrast to existing hypotheses proposed by other authors we discuss a modified sequence leading to C-11 oxidation and, as a consequence, understand epsilon-rhodomycinone as a shunt product...
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