Production of new anthracycline antibiotics 1-hydroxy-oxaunomycin and 6-deoxyoxaunomycin by limited biosynthetic conversion using a daunorubicin-negative mutant.

doi:10.7164/antibiotics.45.1609

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Article

Production of new anthracycline antibiotics 1-hydroxy-oxaunomycin and 6-deoxyoxaunomycin by limited biosynthetic conversion using a daunorubicin-negative mutant.

The Journal of antibiotics - 1 Oct 1992

Yoshimoto A, Johdo O, Tone H, Okamoto R, Naganawa H, Sawa T, Takeuchi T

Abstract excerpt

A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic...

Topics

Animals
Anthracyclines
Antibiotics, Antineoplastic
Carubicin
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
DNA Replication
Daunorubicin
Drug Screening Assays, Antitumor
Leukemia L1210

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Spectroscopy

Mice

Microbiological Techniques

Mutation

Naphthacenes

Streptomyces

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1473988
DOI: 10.7164/antibiotics.45.1609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1473988-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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