Microbial glycosidation of some anthracycline antibiotics by an antibiotic-negative mutant of aclarubicin producer.

doi:10.7164/antibiotics.46.1219

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Article

Microbial glycosidation of some anthracycline antibiotics by an antibiotic-negative mutant of aclarubicin producer.

The Journal of antibiotics - 1 Aug 1993

Johdo O, Tone H, Okamoto R, Yoshimoto A, Naganawa H, Sawa T, Takeuchi T

Abstract excerpt

Microbial conversion of anthracyclinone monosaccharides using aclarubicin-negative mutant of Streptomyces galilaeus was found to produce anthracyclinone disaccharides which had either rhodinose or 2-deoxyfucose as an additional sugar. By this conversion we obtained twelve new anthracyclines from...

Topics

Aclarubicin
Animals
Antibiotics, Antineoplastic
Glycosylation
Leukemia L1210
Mutation
Streptomyces
Structure-Activity Relationship
Tumor Cells, Cultured

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