Genetic alterations in rat colon tumors induced by heterocyclic amines.

doi:10.1002/(SICI)1097-0142(19960415)77:8<1593::AID-CNCR26>3.0.CO;2-U

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Article

Genetic alterations in rat colon tumors induced by heterocyclic amines.

Cancer - 15 Apr 1996

Toyota M, Ushijima T, Kakiuchi H, Canzian F, Watanabe M, Imai K, Sugimura T, Nagao M

Abstract excerpt

BACKGROUND: In rat colon tumors induced by the cooked food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), ras and p53 alterations are rarely detected. To investigate the roles of the APC gene and microsatellite instability (MI) in...

Topics

Animals
Base Sequence
Carcinogens
Colonic Neoplasms
DNA Fingerprinting
DNA, Neoplasm
DNA, Satellite
Genes, APC
Imidazoles
Male
Molecular Sequence Data
Mutagens
Mutation
Quinolines
Rats
Rats, Inbred F344

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