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Food-derived mutagens and carcinogens.

Cancer research - 1 Apr 1992

Wakabayashi K, Nagao M, Esumi H, Sugimura T

Abstract excerpt

Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents when given in the diet at 0.01-0.08%. Most of them induced cancer in the liver and in other organs. It is noteworthy that the most abundant heterocyclic amine in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, produced colon and mammary carcinomas in rats and...

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PMID: 1544146

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