Article
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase.
Carcinogenesis - 1 Jan 2005
Tanaka Takuji, Suzuki Rikako, Kohno Hiroyuki, Sugie Shigeyuki, Takahashi Mami, Wakabayashi Keiji
Abstract excerpt
Heterocyclic amines are known to be important environmental carcinogens in several organs including the colon. The aim of this study was to induce colonic epithelial malignancies within a short-term period and analyze the expression of cycooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and beta-catenin, and mutations of beta-catenin gene in induced tumors. Male Crj: CD-1 mice were given a single i.g....
Topics
- Adenocarcinoma
- Animals
- Anticoagulants
- Base Sequence
- Carcinogens
- Colonic Neoplasms
- Cyclooxygenase 2
- Cytoskeletal Proteins
- Dextran Sulfate