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Article

Neo-angiogenesis in locally advanced squamous cell head and neck cancer correlates with thymidine phosphorylase expression and p53 nuclear oncoprotein accumulation.

Clinical & experimental metastasis - 1 Oct 1998

Giatromanolaki A, Fountzilas G, Koukourakis M I, Arapandoni P, Theologi V, Kakolyris S, Georgoulias V, Harris A L, Gatter K C

Abstract excerpt

Thymidine phosphorylase (Th.P) is an angiogenic factor shown to induce endothelial cell migration and proliferation. On the other hand, loss of wild type p53 function leads to down-regulation of thrombospondin-1, an inhibitor of angiogenesis. In this immunohistochemical study we investigated the intratumoural angiogenesis and thymidine phosphorylase (Th.P) expression in paraffin-embedded bioptical material from...

Read the complete abstract on PubMed

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Share to Carcinoma, Squamous Cell
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Lymphatic Metastasis

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Share to Neovascularization, Pathologic

Share to Proto-Oncogene Proteins c-bcl-2

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9932613
DOI: 10.1023/a:1006554512338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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