Article
Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.
The Journal of cell biology - 1 Aug 1996
Jin P, Gu Y, Morgan D O
Abstract excerpt
The activity of the mitosis-promoting kinase CDC2-cyclin B is normally suppressed in S phase and G2 by inhibitory phosphorylation at Thr14 and Tyr15. This work explores the possibility that these phosphorylations are responsible for the G2 arrest that occurs in human cells after DNA damage. HeLa...
Topics
- CDC2 Protein Kinase
- CDC2-CDC28 Kinases
- Cyclin B
- Cyclin B1
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- Cyclins
- DNA Damage
- Enzyme Repression
- G2 Phase
- HeLa Cells
- Humans
- Mitosis
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Protein Synthesis Inhibitors
- Recombinant Fusion Proteins