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Article

Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.

The Journal of cell biology - 1 Aug 1996

Jin P, Gu Y, Morgan D O

Abstract excerpt

The activity of the mitosis-promoting kinase CDC2-cyclin B is normally suppressed in S phase and G2 by inhibitory phosphorylation at Thr14 and Tyr15. This work explores the possibility that these phosphorylations are responsible for the G2 arrest that occurs in human cells after DNA damage. HeLa cell lines were established in which CDC2AF, a mutant that cannot be phosphorylated at Thr14 and Tyr15, was expressed...

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Identifiers

PMID: 8769420
DOI: 10.1083/jcb.134.4.963
PMCID: PMC2120957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.PMID 8769420Read ↗

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