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Article

Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

The Journal of biological chemistry - 17 Oct 2003

Chow Jeremy P H, Siu Wai Yi, Ho Horace T B, Ma Ken Hoi Tang, Ho Chui Chui, Poon Randy Y C

Abstract excerpt

Inhibition of cyclin-dependent kinases (CDKs) by Thr14/Tyr15 phosphorylation is critical for normal cell cycle progression and is a converging event for several cell cycle checkpoints. In this study, we compared the relative contribution of inhibitory phosphorylation for cyclin A/B1-CDC2 and cyclin A/E-CDK2 complexes. We found that inhibitory phosphorylation plays a major role in the regulation of CDC2 but only a...

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Source

Identifiers

PMID: 12912980
DOI: 10.1074/jbc.M306683200

Genes

CDK2
CDK4
WEE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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