Article
Reduced expression of a human V beta 6.1 T-cell receptor allele.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 1993
Luyrink L, Gabriel C A, Thompson S D, Grom A A, Maksymowych W P, Choi E, Glass D N
Abstract excerpt
We have previously described an allelic polymorphism in the V beta 6.1 T-cell receptor gene. The V beta 6.1B allele is associated with disease in a subgroup of patients with juvenile rheumatoid arthritis. Limited sequence data demonstrated nucleotide differences that resulted in two amino acid ch...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Juvenile
- Base Sequence
- Cloning, Molecular
- Gene Expression
- Genes
- Humans
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic
- RNA, Messenger
- Receptors, Antigen, T-Cell, alpha-beta
- Thymus Gland