B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain.

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Article

B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1996

Maybaum T A, Reynolds J D

Abstract excerpt

To investigate the molecular events associated with B cell apoptosis, we analyzed follicular B cells from the large Peyer's patch (PP) in the sheep ileum. Over 95% of B cells generated in the ileal PP are rapidly destroyed by apoptosis. Ig V lambda sequences from apoptotic B cells were compared w...

Topics

Animals
Antibody Affinity
Antibody Diversity
Apoptosis
B-Lymphocytes
Base Sequence
DNA Mutational Analysis
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Ileum
Immune Tolerance
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin lambda-Chains

Molecular Sequence Data

Mutation

Peyer's Patches

Receptors, Antigen, B-Cell

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 8759728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8759728-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain.PMID 8759728Read ↗

Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches.Semantic proximity Read ↗

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process.Semantic proximity Read ↗

Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius.Semantic proximity Read ↗

Sequence analysis of human IgV<sub>H</sub> genes indicates that ileal lamina propria plasma cells are derived from Peyer's patchesSemantic proximity Read ↗

A New Model of Sheep Ig Diversification: Shifting the Emphasis Toward Combinatorial Mechanisms and Away from HypermutationSemantic proximity Read ↗

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The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.Semantic proximity Read ↗

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