Article
Sequence analysis of human IgV<sub>H</sub> genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches
1 Feb 1997
Abstract excerpt
The origin of human ileal lamina propria (LP) plasma cells has been investigated using a technique based on microdissection of cells from immunohistochemically stained tissue sections. We have sequenced rearranged IgVH4.2 1, IgVH 5 family and IgVH6 genes from Peyer's patch germinal center (GC) cells and plasma cells from the ileal LP. Clonally related cells were identified by comparison of their complementarity...
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