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Article

Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius.

1 Jan 1995

Abstract excerpt

The vast majority of lymphocytes generated daily in the chicken bursa of Fabricius do not emigrate to the periphery but die in situ. Apoptotic cells in the bursa can be readily detected by the presence of fragmented DNA and by the large numbers of condensed cellular nuclei observed by electron microscopy. Consequently, most newly generated lymphocytes die by programmed cell death. We show that bursal cells divide...

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Identifiers

PMID: 7806997
DOI: 10.1084/jem.181.1.105

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Source receipt: pubmed, retrieved 7 Sept 2026.

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