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Article

A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2017

Aberdein Danielle, Munday John S, Gandolfi Barbara, Dittmer Keren E, Malik Richard, Garrick Dorian J, Lyons Leslie A

Abstract excerpt

British shorthair (BSH) kittens in multiple litters died as a result of a severe non-neoplastic lymphoproliferative disease that showed many similarities with human autoimmune lymphoproliferative syndrome (ALPS). Human ALPS is caused by inherited defects in FAS-mediated lymphocyte apoptosis and the possibility of similar defects was investigated in BSH cats. The whole genomes of two affected kittens were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27770190
DOI: 10.1007/s00335-016-9668-1

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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