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Article

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process.

Cell - 13 Jan 1995

Reynaud C A, Garcia C, Hein W R, Weill J C

Abstract excerpt

Somatic hypermutation of light chain V genes during development of B cells in sheep ileal Peyer's patches was studied in three experimental conditions: in sterile fragments of the ileum surgically isolated from the gut during fetal life, in germ-free sheep, and in animals thymectomized during early fetal life. The somatic mutation pattern was found identical to control tissues in all three experiments. The same...

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Identifiers

PMID: 7813007
DOI: 10.1016/0092-8674(95)90456-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process.PMID 7813007Read ↗

Developmental progression of immunoglobulin heavy chain diversity in sheep.Semantic proximity Read ↗

Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches.Semantic proximity Read ↗

Diversification of sheep immunoglobulins.Semantic proximity Read ↗

B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain.Semantic proximity Read ↗

A New Model of Sheep Ig Diversification: Shifting the Emphasis Toward Combinatorial Mechanisms and Away from HypermutationSemantic proximity Read ↗

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.Semantic proximity Read ↗

Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.Semantic proximity Read ↗

The sheep Ig variable region repertoire consists of a single VH familySemantic proximity Read ↗

Origin and maintenance of germ-line V genes.Semantic proximity Read ↗

A single VH family and long CDR3s are the targets for hypermutation in bovine immunoglobulin heavy chains.Semantic proximity Read ↗

Activation-induced cytidine deaminase (AID) is strongly expressed in the fetal bovine ileal Peyer's patch and spleen and is associated with expansion of the primary antibody repertoire in the absence of exogenous antigens.Semantic proximity Read ↗

Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals.Semantic proximity Read ↗

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