Article
Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process.
Cell - 13 Jan 1995
Reynaud C A, Garcia C, Hein W R, Weill J C
Abstract excerpt
Somatic hypermutation of light chain V genes during development of B cells in sheep ileal Peyer's patches was studied in three experimental conditions: in sterile fragments of the ileum surgically isolated from the gut during fetal life, in germ-free sheep, and in animals thymectomized during ear...
Topics
- Animals
- Antigens
- B-Lymphocytes
- Base Composition
- Base Sequence
- Codon
- Gene Rearrangement
- Genes, Immunoglobulin
- Germ-Free Life
- Immunoglobulin Joining Region
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains
- Molecular Sequence Data
- Mutation
- Peyer's Patches
- Phenotype
- Sheep