Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway.

doi:10.1016/s1074-7613(00)80312-x

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Article

Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway.

Immunity - 1 Jul 1996

Hilbert D M, Migone T S, Kopf M, Leonard W J, Rudikoff S

Abstract excerpt

The development of murine plasma cell tumors induced by raf/myc containing retroviruses is facilitated by T cells and completely dependent on IL-6. To determine whether kinases with differing specificities reflect alternative biochemical pathways in B cell tumorigenesis, we have employed an abl/m...

Topics

Animals
Base Sequence
Genes, abl
Interleukin-6
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Mice, Nude
Molecular Sequence Data
Phenotype
Plasmacytoma
Retroviridae Infections
Signal Transduction
Tumor Virus Infections

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