Article
v-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice.
Oncogene - 1 Apr 1990
Kurie J M, Morse H C, Principato M A, Wax J S, Troppmair J, Rapp U R, Potter M, Mushinski J F
Abstract excerpt
In a variety of systems, evidence is accumulating which suggests that neoplastic transformation requires the action of two or more genes such as mutated or over-expressed proto-oncogenes. To determine whether the cytoplasmic serine/threonine kinase oncogene raf could complement a deregulated myc gene and induce tumors in adult mice, BALBC mice were primed with an intraperitoneal (ip.) injection of mineral oil...
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