Article
v-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice.
Oncogene - 1 Apr 1990
Kurie J M, Morse H C, Principato M A, Wax J S, Troppmair J, Rapp U R, Potter M, Mushinski J F
Abstract excerpt
In a variety of systems, evidence is accumulating which suggests that neoplastic transformation requires the action of two or more genes such as mutated or over-expressed proto-oncogenes. To determine whether the cytoplasmic serine/threonine kinase oncogene raf could complement a deregulated myc...
Topics
- Animals
- B-Lymphocytes
- Blotting, Northern
- Blotting, Southern
- Carcinogens
- Cell Transformation, Neoplastic
- DNA, Neoplasm
- Gene Rearrangement
- Lymphoma
- Mice
- Mice, Inbred BALB C
- Mutation
- Oncogene Protein p55(v-myc)
- Oncogene Proteins v-raf
- Oncogenes
- Protein-Tyrosine Kinases
- Proto-Oncogenes
- RNA, Neoplasm