Article
Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells.
The Journal of biological chemistry - 12 Aug 2011
Yang Yanqiang, Groshong Jason S, Matta Hittu, Gopalakrishnan Ramakrishnan, Yi Han, Chaudhary Preet M
Abstract excerpt
Myeloma cells are dependent on IL6 for their survival and proliferation during the early stages of disease, and independence from IL6 is associated with disease progression. The role of the NF-κB pathway in the IL6-independent growth of myeloma cells has not been studied. Because human herpesvirus 8-encoded K13 selectively activates the NF-κB pathway, we have used it as a molecular tool to examine the ability of...
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