Article
A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule.
Immunity - 1 Jul 1996
Gulden P H, Fischer P, Sherman N E, Wang W, Engelhard V H, Shabanowitz J, Hunt D F, Pamer E G
Abstract excerpt
Polymorphism of MHC class Ia molecules severely constrains vaccine development against intracellular pathogens. Antigen presentation by MHC class Ib molecules, which are generally conserved between different individuals, may circumvent this obstacle. Herein, we use tandem mass spectrometry to identify a Listeria monocytogenes pentapeptide antigen that is presented to T lymphocytes by the H2-M3 MHC class Ib...
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