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Article

Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense.

The Journal of experimental medicine - 20 Feb 2006

Xu Honglin, Chun Taehoon, Choi Hak-Jong, Wang Bin, Wang Chyung-Ru

Abstract excerpt

The major histocompatibility complex (MHC) class Ib molecule H2-M3 primes the rapid expansion of CD8+ T cells by presenting N-formylated bacterial peptides. However, the significance of H2-M3-restricted T cells in host defense against bacteria is unclear. We generated H2-M3-deficient mice to investigate the role of H2-M3 in immunity against Listeria monocytogenes (LM), a model intracellular bacterial pathogen....

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Share to CD8-Positive T-Lymphocytes
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

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Source

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Identifiers

PMID: 16476767
DOI: 10.1084/jem.20051866
PMCID: PMC2118219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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