Article

Data-independent immunopeptidomics discovery of low-abundant bacterial epitopes

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Mass spectrometry-based immunopeptidomics is a powerful approach to uncover peptides presented by human leukocyte antigen (HLA) molecules that can guide vaccine design and immunotherapies. While data-dependent acquisition (DDA) has been the standard for navigating through the complexity associated with non-enzymatic immunopeptide database searches, data-independent acquisition (DIA) is increasin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eddd80be-1676-512c-af58-ebef53ed4ab1
DOI: 10.1101/2025.05.14.653952

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Data-independent immunopeptidomics discovery of low-abundant bacterial epitopesDOI 10.1101/2025.05.14.653952Read

Generation of HLA Allele-Specific Spectral Libraries to Identify and Quantify Immunopeptidomes by SWATH/DIA-MS.Semantic proximity Read

Immunopeptidomics for Dummies: Detailed Experimental Protocols and Rapid, User-Friendly Visualization of MHC I and II Ligand Datasets with MhcVizPipeSemantic proximity Read

High-coverage immunopeptidomics using timsTOF mass spectrometers with Thunder-DDA-PASEF boosted by MS2RescoreSemantic proximity Read

Removing the hidden data dependency of DIA with predicted spectral librariesSemantic proximity Read

Pitfalls in HLA Ligandomics—How to Catch a Li(e)gandSemantic proximity Read

SAPrIm, a semi-automated protocol for mid-throughput immunopeptidomicsSemantic proximity Read

LooMS: a novel peptide identification tools for data independent acquisitionSemantic proximity Read

Sensitive neoantigen discovery by real-time mutanome-guided immunopeptidomicsSemantic proximity Read

MHCquant2 refines immunopeptidomics tumor antigen discoverySemantic proximity Read

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysisSemantic proximity Read

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysisSemantic proximity Read

TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identificationSemantic proximity Read