Article
Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3.
Immunity - 1 Jul 1996
Lenz L L, Dere B, Bevan M J
Abstract excerpt
Using expression cloning, we have identified an H2-M3-restricted epitope of the intracellular bacterial pathogen Listeria monocytogenes. Picomolar concentrations of an amino-terminal N-formylated hexapeptide, fMIGWII, targeted cells for lysis by CD8+ cytotoxic T cells, while the nonformylated pep...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Antigens, Bacterial
- Bacterial Proteins
- Base Sequence
- Cytotoxicity, Immunologic
- Epitopes
- Gene Library
- H-2 Antigens
- Listeria monocytogenes
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- T-Lymphocytes, Cytotoxic
- Transformation, Bacterial