Article
The Emu-bcl-2 transgene enhances antigen-induced germinal center formation in both BALB/c and SJL mice but causes age-dependent germinal center hyperplasia only in the lymphoma-prone SJL strain.
The American journal of pathology - 1 Aug 1995
Secord E A, Edington J M, Thorbecke G J
Abstract excerpt
Emu-bcl-2 transgenic and littermate control BALB/c and SJL mice were immunized in the front footpads with trinitrophenylated Brucella abortus and the germinal center (GC) response in draining brachial lymph nodes was studied by staining with peanut agglutinin peroxidase and methyl green. Although...
Topics
- Aging
- Animals
- Antibody Formation
- Brucella abortus
- Dexamethasone
- Drug Resistance
- Genes
- Genetic Predisposition to Disease
- Hyperplasia
- Immunization
- Lymph Nodes
- Lymphoma
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains
- Mice, Transgenic
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2