Article
Invasion of primary nasopharyngeal epithelial cells by Neisseria meningitidis is controlled by phase variation of multiple surface antigens.
Infection and immunity - 1 Aug 1996
de Vries F P, van Der Ende A, van Putten J P, Dankert J
Abstract excerpt
We have investigated bacterial factors required for the entry of Neisseria meningitidis serogroup B into mucosal cells using a novel in vitro infection model of primary cultures of human nasopharyngeal epithelium. An invasive meningococcal phenotype was obtained after several cycles of selection...
Topics
- Antigens, Bacterial
- Bacterial Adhesion
- Bacterial Capsules
- Bacterial Outer Membrane Proteins
- Cells, Cultured
- Child
- Child, Preschool
- Epithelial Cells
- Epithelium
- Fimbriae, Bacterial
- Genetic Variation
- Humans
- Infant
- Lipopolysaccharides
- Nasopharynx
- Neisseria meningitidis
- Phenotype