Article
Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides.
Molecular microbiology - 1 Nov 1995
Virji M, Makepeace K, Peak I R, Ferguson D J, Jennings M P, Moxon E R
Abstract excerpt
The interplay between four surface-expressed virulence factors of Neisseria meningitidis (pili, Opc, capsule and lipopolysaccharide (LPS)) in host cell adhesion and invasion was examined using derivatives of a serogroup B strain, MC58, created by mutation (capsule, Opc) and selection of variants....
Topics
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Blood Proteins
- Blotting, Western
- Cells, Cultured
- Cloning, Molecular
- Electrophoresis, Polyacrylamide Gel
- Endothelium
- Fimbriae, Bacterial
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genetic Variation
- Humans
- Lipopolysaccharides