Article
Neisseria meningitidis undergoes PilC phase variation and PilE sequence variation during invasive disease.
The Journal of infectious diseases - 1 Feb 2004
Rytkönen Anne, Albiger Barbara, Hansson-Palo Paola, Källström Helena, Olcén Per, Fredlund Hans, Jonsson Ann-Beth
Abstract excerpt
Neisseria meningitidis colonizes the upper respiratory tract (URT), enters the blood stream, and reaches the cerebrospinal fluid (CSF). In the present study, we show that bacteria isolated from the URT adhere better to human epithelial cells, compared with bacteria from blood or CSF, which suggests that important changes of virulence-associated proteins take place during bacterial dissemination. Phase variation...
Topics
- Amino Acid Sequence
- Bacterial Adhesion
- Cell Line, Tumor
- Epithelial Cells
- Fimbriae Proteins
- Fimbriae, Bacterial
- Genetic Variation
- Humans
- Meningococcal Infections
- Molecular Sequence Data
- Neisseria meningitidis
- Respiratory Tract Infections
- Sequence Alignment