Article
Phase variation of lipopolysaccharide directs interconversion of invasive and immuno-resistant phenotypes of Neisseria gonorrhoeae.
The EMBO journal - 1 Nov 1993
van Putten J P
Abstract excerpt
Phase variation of Neisseria gonorrhoeae lipopolysaccharide (LPS) controls both bacterial entry into human mucosal cells, and bacterial susceptibility to killing by antibodies and complement. The basis for this function is a differential sialylation of the variable oligosaccharide moiety of the L...
Topics
- Adaptation, Biological
- Cells, Cultured
- Complement Activation
- Cytidine Monophosphate N-Acetylneuraminic Acid
- Epithelium
- Epitopes
- Genetic Variation
- Humans
- Intestinal Mucosa
- Lipopolysaccharides
- N-Acetylneuraminic Acid
- Neisseria gonorrhoeae
- Oligosaccharides
- Phenotype
- Sialic Acids
- Virulence