Article
Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors.
Molecular microbiology - 1 Mar 1998
de Vries F P, Cole R, Dankert J, Frosch M, van Putten J P
Abstract excerpt
Neisseria meningitidis possesses a repertoire of surface adhesins that promote bacterial adherence to and entry into mammalian cells. Here, we have identified heparan sulphate proteoglycans as epithelial cell receptors for the meningococcal Opc invasin. Binding studies with radiolabelled heparin and heparin affinity chromatography demonstrated that Opc is a heparin binding protein. Subsequent binding experiments...
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