Regulation of IgM and IgD heavy chain gene expression: effect of abrogation of intergenic transcriptional termination.

Abstract excerpt

Early IgM+ B cells express little or no membrane IgD due to the low abundance of delta mRNA. Extensive transcriptional termination regulated by sequences in the intronic region between mu and delta heavy chain genes may be the primary reason for the lack of delta gene transcription. We have examined the effect of deletion of these sequences on the regulation of IgM and IgD heavy chain gene expression in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Line
• Share to Exons
• Share to Gene Expression Regulation