Article
Repositioning of an alternative exon sequence of mouse IgM pre-mRNA activates splicing of the preceding intron.
Gene expression - 1 Jan 1991
Watakabe A, Sakamoto H, Shimura Y
Abstract excerpt
Using a transient expression system of mouse IgM mini-gene constructs in mouse B-cell lines and in fibroblast L cell, we investigated splicing of the IgM transcript. We observed that the efficiency of splicing between exons C4 and M1 (C4-to-M1 splicing), the splicing reaction leading to the production of membrane-bound form (microns) mRNA, was drastically affected by mutations in a specific portion of the...
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